One of the difficulties I have is that a great deal of my information comes from various sources (blogs, newsletters, academic papers, website, etc). And while many of those have blog like platforms and thus can be read in google reader, many do not (see a lot of the institutional reads on the sidebar as an example).
I am designing a website, mainly for my own benefit that may even be private, that will likely aggregate most of what I want to read. If you have experimented with the idea, or know of a better solution, please let me know…
